Histological Features of Different Organs Before and After Treatment of Diabetes by Using Avocado Extract in Rats

Aim of the study: The present study aimed to histological features different organs before and after treatment diabetes by using avocado extract in rats. Materials methods: Hot aqueous extraction was performed. Forty male rats (weighted 140–190g) were used this study. Following time acclimatization, animals had an overnight fast 18 hours being prepped for alloxan monohydrate-induced diabetes. Before induction, measurements animals' body weights blood glucose levels made. However, received IP injection 150 mg/kg bw. that, rats' tracked every day 3 weeks establish a stable glucose. divided into 4 groups: Group 1 got water as non-induced (negative control) condition. Alloxan-induced 2 positive control. 3: extract-treated only given 40 g/L dose avocado. Pancreas, livers, well kidneys from control, alloxanized, treated taken at times, processed utilized examination preserved 10% formaldehyde till processing staining. Results: current results showed significant difference between groups especially G3 weeks. G2 exhibited depleted islet cells regions cell necrosis. tiny, (PIL) diabetic with week (G3) improvement compared G2. As days advanced, more improvements seen pancreatic architecture extract, including presence noticeable exocrine cells. intact G3, caused healing tissue extracts. Alloxanized (G2) necrosis infiltrations inflammatory course therapy continued, it became clear that improved, glomeruli fewer (G3). Livers visible necrosis, when histology G1 G4. After receiving medication, group compact, healthy liver tissues three In conclusion, pancreas, kidneys, all protected enhancement levels. KEY WORDS: Diabetes, Avocado, Histology, Rats.